http://docs.cksource.com/CKEditor_3.x/Developers_Guide/Styles#Using_an_External_Styles_Definition_File
CKEDITOR.editorConfig = function( config )
{
// Define changes to default configuration here. For example:
// config.language = 'fr';
// config.uiColor = '#AADC6E';
config.stylesSet = 'my_styles:/var/www/html/drupal6/sites/domain.com/libraries/plugins/styles/styles/mystyles.js';
};
CKEDITOR.stylesSet.add( 'my_styles',
[
// Block-level styles
{ name : 'test', element : 'h2', styles : { 'color' : 'Blue' } },
// Inline styles
{ name : 'test', element : 'span', attributes : { 'class' : 'my_style' } },
]);